1 Based on lower Plaque Index (PI), Probing Depth (PD), and Bleeding on Probing (BOP) of the upper right first molar and upper left central incisors at initial, 1 month and 3 months on 77 patients (age 16-30, 32 Invisalign treatment, 35 fixed appliances, 10 control) in Class I mild crowding cases. Levrini L, et al. Periodontal health status in patients treated with the Invisalign® system and fixed orthodontic appliances: A 3 months clinical and microbiological evaluation. Eur J Dent 2015;9:404-10.

2 https://www.aaoinfo.org/blog/orthodontic-treatment-with-clear-aligners/

3 Study sponsored by Align Technology and based on adult Class I, nonextraction, mild to moderate crowding cases with SmartTrack material. David W. White, Katie C. Julien, Helder Jacob, Phillip M. Campbell and Peter H. Buschang, Discomfort associated with Invisalign and traditional brackets: A randomized, prospective trial. The Angle Orthodontist Nov 2017, Vol. 87, No. 6 pp. 801-808

4 https://www.aaoinfo.org/wp-content/uploads/2020/03/AAO_HandlingOrthoIssuesAtHome_2020.pdf

5 https://www.webmd.com/oral-health/invisible-orthodontic-aligners#1

6 Compared to Invisalign aligners previously made from single-layer (EX30) material. In a study by Miller et al, with adults measuring pain in the first week of treatment.  Kevin Miller et al.  “A comparison of treatment impacts between Invisalign aligner and fixed appliance therapy during the first week of treatment.”  American Journal of Orthodontics and Dentofacial Orthopedics.  Volume 131, Issue 3, pp. 302. e1-302.e9, March 2007.

7 Compared to Invisalign aligners previously made from single-layer (EX30) material.

8  https://www.aaoinfo.org/blog/orthodontic-treatment-with-clear-aligners/

9 The availability of the iTero scanner is dependent on your Invisalign provider.

10 https://caortho.org/blog/mail-order-braces

11 Worldwide data on file at Align Technology, Data on file at Align Technology, June 30, 2022.